Performance and Operational Feasibility of Epstein-Barr Virus-Based Screening for Detection of Nasopharyngeal Carcinoma: Direct Comparison of Two Alternative Approaches.

Pei-Jen Lou Wai Kei Jacky LamWan-Lun HsuRuth M Pfeiffer Kelly J YuCharles M L ChanVicky C T LeeTseng-Cheng Chen Shyuang-Der TerngYung-An TsouYi-Shing LeuLi-Jen LiaoYen-Liang ChangYin-Chu ChienCheng-Ping WangChing-Yuan LinChun-Hung HuaJehn-Chuan LeeTsung-Lin YangChuhsing Kate HsiaoMing-Shiang WuMing-Hsui TsaiHung Chun Skye Cheng Allan Hildesheim Chien-Jen Chen Allen K C Chan Zhiwei Liunull null

Published in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2023)

We demonstrated high sensitivity and specificity of EBV antibody and plasma EBV DNA for NPC detection, with slightly inferior performance of the EBV antibody score. Cost-effectiveness studies are needed to guide screening implementation.

Keyphrases

epstein barr virus
diffuse large b cell lymphoma
loop mediated isothermal amplification
real time pcr
healthcare
primary care
quality improvement
case control
sensitive detection