Novel lysine-specific histone demethylase 1 inhibitor in acute myeloid leukaemia transformed from essential thrombocythaemia.

Published in: Cancer reports (Hoboken, N.J.) (2021)

We report a case of an older adult with secondary AML transformed from ET, with a remarkable response to LSD1 inhibition with Bomedemstat, with prolonged reduction in blasts demonstrating differentiation to monocytes.

Keyphrases

acute myeloid leukemia
dendritic cells
liver failure
respiratory failure
dna methylation
bone marrow
physical activity
aortic dissection
community dwelling
drug induced
middle aged
peripheral blood
gene expression
hepatitis b virus
intensive care unit
young adults
childhood cancer
acute lymphoblastic leukemia