High prevalence of multidrug resistant ESBL- and plasmid mediated AmpC-producing clinical isolates of Escherichia coli at Maputo Central Hospital, Mozambique.
Calvina E L EstalevaTomas F ZimbaJohn Osei SekyereUsha GovindenHafizah Y CheniaGunnar S SimonsenBjørg HaldorsenSabiha Y EssackArnfinn SundsfjordPublished in: BMC infectious diseases (2021)
We have observed a high prevalence of MDR pAmpC- and/or ESBL-producing clinical E. coli isolates with FOX/MOX and CTX-Ms as the major β-lactamase types, respectively. ERIC-PCR analyses revealed genetic diversity and some clusters indicating within-hospital spread. The overall findings strongly support the urgent need for accurate and rapid diagnostic services to guide antibiotic treatment and improved infection control measures.
Keyphrases
- escherichia coli
- genetic diversity
- klebsiella pneumoniae
- multidrug resistant
- healthcare
- drug resistant
- gram negative
- acinetobacter baumannii
- biofilm formation
- acute care
- mass spectrometry
- primary care
- adverse drug
- multiple sclerosis
- mental health
- high resolution
- single cell
- crispr cas
- health insurance
- sensitive detection
- replacement therapy
- cystic fibrosis
- affordable care act