ADAMTS13 activity to von Willebrand factor antigen ratio predicts acute kidney injury in patients with COVID-19: Evidence of SARS-CoV-2 induced secondary thrombotic microangiopathy.

Brandon Michael HenryStefanie W BenoitMaria Helena Santos de OliveiraGian Luca SalvagnoEmmanuel J FavaloroJustin L Benoit

Published in: International journal of laboratory hematology (2020)

A low ADAMTS13 activity:VWF:Ag ratio at ED presentation is associated with progression to severe COVID-19 disease and severe AKI, with a pattern suggestive of a secondary microangiopathy. Further interventional studies should be conducted to assess the restoration of ADAMTS13:VWF:Ag ratio in hospitalized patients with COVID-19.

Keyphrases

sars cov
quantum dots
early onset
emergency department
coronavirus disease
drug induced
respiratory syndrome coronavirus
high glucose
diabetic rats
highly efficient
oxidative stress
endothelial cells