Triggering receptors expressed on myeloid cells (TREMs) encompass a family of cell-surface receptors chiefly expressed by granulocytes, monocytes and tissue macrophages. These receptors have been implicated in inflammation, neurodegenerative diseases, bone remodelling, metabolic syndrome, atherosclerosis and cancer. Here, I review the structure, ligands, signalling modes and functions of TREMs in humans and mice and discuss the challenges that remain in understanding TREM biology.
Keyphrases
- metabolic syndrome
- cell surface
- induced apoptosis
- dendritic cells
- oxidative stress
- cardiovascular disease
- papillary thyroid
- bone marrow
- insulin resistance
- bone mineral density
- acute myeloid leukemia
- squamous cell carcinoma
- immune response
- signaling pathway
- adipose tissue
- soft tissue
- skeletal muscle
- postmenopausal women