Comorbidities, mortality and metabolic profile in individuals with primary biliary cholangitis-A Phenome-Wide-Association-Study.
Paul-Henry KoopConstanze SchwenzerJan ClusmannMara Sophie VellJulius JaegerWenfang GuiChristian TrautweinAlexander KochKaren SchmidtCarolin Victoria SchneiderKai Markus SchneiderPublished in: Liver international : official journal of the International Association for the Study of the Liver (2024)
Our study provides a detailed perspective on the morbidity of individuals with PBC. The exploration of potential effects of disease state on morbidity suggest that early detection and early treatment of PBC could enhance patient prognosis and prevent the onset of comorbid diseases. Finally, the metabolomic alterations could represent a link between the pathophysiological processes underlying PBC development, progression, and associated morbidity.