Host-Microbe Multiomic Profiling Reveals Age-Dependent COVID-19 Immunopathology.

Hoang Van PhanAlexandra TsitsiklisCole P MaguireElias K HaddadPatrice M BeckerSeunghee Kim-SchulzeBrian LeeJing ChenAnnmarie HochHarry PickeringPatrick Van ZalmMatthew C AltmanAlison D AugustineCarolyn S CalfeeSteve BosingerCharles CairnsWalter EckalbarLeying GuanNaresh Doni JayaveluSteven H KleinsteinFlorian KrammerHolden T MaeckerAl OzonoffBjoern PetersNadine Rouphaelnull nullRuth R MontgomeryElaine ReedJoanna SchaenmanHanno Steen Ofer Levy Joann Diray-ArceCharles R Langelier

Published in: medRxiv : the preprint server for health sciences (2024)

We observed age-dependent immune dysregulation at the transcriptional, protein and cellular levels, manifesting in an imbalance of inflammatory responses over the course of hospitalization, and suggesting potential new therapeutic targets.

Keyphrases

coronavirus disease
sars cov
gene expression
protein protein
binding protein
respiratory syndrome coronavirus
heat shock
oxidative stress
small molecule