Relapsed Babesia microti Infection Following Allogeneic Hematopoietic Cell Transplantation in a Patient With B-cell Acute Lymphoblastic Leukemia: Case Report and Review of the Literature.
Joshua RosenblattAnnie LeungEmily BanemanRisa N FullerSarah TaimurAlberto Paniz MondolfiAdriana K MaloneLaura A KirkmanSamantha E JacobsPublished in: Open forum infectious diseases (2021)
A patient with relapsed/refractory B-cell acute lymphoblastic leukemia developed babesiosis before allogeneic hematopoietic cell transplantation while on atovaquone for Pneumocystis jirovecii pneumonia prophylaxis. Despite receiving a prolonged course of atovaquone and azithromycin until whole-blood Babesia microti DNA was no longer detected by polymerase chain reaction, her post-transplant course was complicated by relapsed babesiosis. We investigate the potential host and parasite characteristics causing relapsing/persistent infection.
Keyphrases
- acute lymphoblastic leukemia
- stem cell transplantation
- allogeneic hematopoietic stem cell transplantation
- case report
- bone marrow
- multiple sclerosis
- hematopoietic stem cell
- acute myeloid leukemia
- circulating tumor
- cell free
- intensive care unit
- climate change
- human health
- systemic lupus erythematosus
- extracorporeal membrane oxygenation
- life cycle