Role of TGF-β in pancreatic ductal adenocarcinoma progression and PD-L1 expression.
S Mazher HussainRita G KansalMarcus A AlvarezT J HollingsworthAbul ElahiGustavo Miranda-CarboniLeah E HendrickAjeeth K PingiliLorraine M AlbrittonPaxton V DicksonJeremiah L DeneveDanny YakoubD Neil HayesMichio KurosuDavid ShibataLiza MakowskiEvan S GlazerPublished in: Cellular oncology (Dordrecht) (2021)
In PDAC, the non-SMAD-TGF-β signaling pathway leads to more aggressive phenotypes, TAM-induced immunosuppression and PD-L1 expression. The divergent effects of TGF-β ligand versus receptor inhibition in tumor cells versus TAMs may explain the TGF-β paradox. Further evaluation of each mechanism is expected to lead to the development of targeted therapies.