Ovarian Cancer in a Northern Italian Province and the Multidisciplinary Team.
Lucia MangoneFrancesco MarinelliIsabella BiscegliaMaria Barbara BraghiroliValentina MastrofilippoLoredana CerulloCarlotta PellegriAlessandro ZambelliLorenzo AguzzoliVincenzo Dario MandatoPublished in: Cancers (2022)
Ovarian cancer represents one of the most aggressive female cancers in the world, remaining a tumor with high lethality. This study aims to present how a multidisciplinary team (MDT) approach can improve the prognosis in terms of recurrence and death of patients. In total, 448 ovarian cancer cases registered in an Italian Cancer Registry between 2012 and 2020 were included. Information on age, morphology, stage, and treatment was collected. Recurrence and death rates were reported 1 and 2 years after diagnosis, comparing MDT vs. non-MDT approaches. Ninety-three percent had microscopic confirmation, and most showed cystic-mucinous morphology. In total, 50% were older than 65 years old. The distribution by stage was 17.6%, 4%, 44.9%, and 32.6% for stages I, II, III, and IV, respectively. The women followed by the MDT were 24.1%. Disease-free survival 1-year post-diagnosis, recurrences, recurrences-deaths, and deaths were 67.5%, 14.5%, 8.4%, and 9.6%, respectively, better than the non-MDT group (46.2%, 13.2%, 20.8 %, and 19.8%, respectively) (p < 0.01). The same positive results were confirmed two years after diagnosis, particularly for stages III and IV. Albeit small numbers, the study confirms a better prognosis for women managed by MDT with fewer recurrences and deaths, especially within the first 24 months of diagnosis.
Keyphrases
- free survival
- end stage renal disease
- polycystic ovary syndrome
- quality improvement
- chronic kidney disease
- palliative care
- newly diagnosed
- ejection fraction
- squamous cell carcinoma
- papillary thyroid
- adipose tissue
- young adults
- high grade
- health information
- patient reported outcomes
- breast cancer risk
- lymph node metastasis
- childhood cancer