Risk factors for Clostridium difficile infection in pediatric inpatients: A meta-analysis and systematic review.
Scott AnjewierdenZheyi HanCharles B FosterChaitanya PantAbhishek DeshpandePublished in: Infection control and hospital epidemiology (2019)
Prior antibiotic exposure appears to be an important risk factor for CDI based on the combined analysis but not significant using adjusted studies. PPI use was associated with an increased risk of CDI. Judicious and appropriate use of antibiotics and PPIs may help reduce the risk of CDI in this vulnerable population.