Small-molecule Akt-activation in airway cells induces NO production and reduces IL-8 transcription through Nrf-2.

Indiwari GopallawaLi Eon KuekNithin D AdappaJames N PalmerRobert J Lee

Published in: Respiratory research (2021)

Together, the data presented here demonstrate SC79 activation of Akt induces potentially anti-pathogenic NO production, antioxidant gene transcription, reduces IL-8 transcription, and may protect against oxidative barrier dysfunction in a wide range of airway epithelial cells.

Keyphrases

small molecule
oxidative stress
induced apoptosis
transcription factor
signaling pathway
cell proliferation
cell cycle arrest
genome wide
electronic health record
copy number
big data
protein protein
machine learning
deep learning
genome wide analysis