Allogeneic CAR Invariant Natural Killer T Cells Exert Potent Antitumor Effects through Host CD8 T-Cell Cross-Priming.
Federico SimonettaJuliane K LohmeyerToshihito HiraiKristina Maas-BauerMaite AlvarezArielle S WenokurJeanette BakerAmin AalipourXuhuai JiSamuel HaileCrystal L MackallRobert S NegrinPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
In addition to their known direct cytotoxic effect, allogeneic CAR iNKT cells induce host CD8 T-cell antitumor responses, resulting in a potent antitumor effect lasting longer than the physical persistence of the allogeneic cells. The utilization of off-the-shelf allogeneic CAR iNKT cells could meet significant unmet needs in the clinic.