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Allogeneic CAR Invariant Natural Killer T Cells Exert Potent Antitumor Effects through Host CD8 T-Cell Cross-Priming.

Federico SimonettaJuliane K LohmeyerToshihito HiraiKristina Maas-BauerMaite AlvarezArielle S WenokurJeanette BakerAmin AalipourXuhuai JiSamuel HaileCrystal L MackallRobert S Negrin
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
In addition to their known direct cytotoxic effect, allogeneic CAR iNKT cells induce host CD8 T-cell antitumor responses, resulting in a potent antitumor effect lasting longer than the physical persistence of the allogeneic cells. The utilization of off-the-shelf allogeneic CAR iNKT cells could meet significant unmet needs in the clinic.
Keyphrases
  • stem cell transplantation
  • induced apoptosis
  • bone marrow
  • cell cycle arrest
  • hematopoietic stem cell
  • cell death
  • primary care
  • oxidative stress
  • signaling pathway
  • mental health
  • low dose
  • cell proliferation