Radiosynthesis and Preclinical Evaluation of an α2A-Adrenoceptor Tracer Candidate, 6-[18F]Fluoro-marsanidine.

Anna KrzyczmonikThomas KellerFrancisco R López-PicónSarita ForsbackAnna K KirjavainenJatta S TakkinenAleksandra WasilewskaMika ScheininMerja Haaparanta-SolinFranciszek SączewskiOlof Solin

Published in: Molecular imaging and biology (2020)

6-[18F]Fluoro-marsanidine was synthesized and evaluated as a PET tracer candidate for brain α2A-adrenoceptors. However, rapid metabolism, extensive presence of labeled metabolites in the brain, and high non-specific uptake in mouse and rat brain make 6-[18F]fluoro-marsanidine unsuitable for α2A-adrenoceptor targeting in rodents in vivo.

Keyphrases

positron emission tomography
pet imaging
computed tomography
resting state
white matter
pet ct
functional connectivity
ms ms
cerebral ischemia
stem cells
cancer therapy
cell therapy
bone marrow
mesenchymal stem cells