Opioid-induced microbial dysbiosis disrupts CPT-11 metabolism and increases gastrointestinal toxicity in a murine model.

Jingjing MengYaa F AbuYue ZhangYuyin ZhouYun XieYan YanJunyi TaoSundaram RamakrishnanChi ChenSabita Roy

Published in: British journal of pharmacology (2022)

Gut microbiota play a significant role in opioid and chemotherapeutic agent drug-drug interactions. Inhibition of gut microbial glucuronidase may also prevent adverse GI effects of CPT-11 in patients on opioids.

Keyphrases

chronic pain
pain management
end stage renal disease
microbial community
ejection fraction
chronic kidney disease
oxidative stress
peritoneal dialysis
prognostic factors
drug induced
high glucose
emergency department
adverse drug
stress induced