Sex-differences in excess death risk during the COVID-19 pandemic: an analysis of the first wave across Italian regions. What have we learned?

In this commentary, we bring together knowledge on sex-differences in excess death during the first wave of the COVID-19 pandemic in Italy, one of the most hit European countries. We zoom into Italian regions to account for the spatial gradient of the spread of the virus. Analyses of excess death by sex during the COVID-19 pandemic have been possible thanks to weekly mortality data released by national statistical offices, mainly in developed countries. The general finding is that males up to 75 years old have been suffering more excess death compared to females. However, the picture is less clear-cut at older ages. During previous epidemics, such as SARS, Swine Flu, and MERS, studies are limited and produce scattered, non-conclusive evidence. Knowledge of the sex-pattern of susceptibility to mortality from virulent respiratory diseases and its interplay with age could improve crisis management during future epidemics and pandemics. National statistical offices should provide weekly mortality data with spatial granularity, disaggregated by sex and age groups, to allow for such analyses.