Assessment of DNA Methylation Patterns in the Bone and Cartilage of a Nonhuman Primate Model of Osteoarthritis.

Genevieve HousmanLorena M HavillEllen E QuillenAnthony G ComuzzieAnne C Stone

Published in: Cartilage (2018)

Overall, the 450K array can be used to measure genome-wide DNA methylation in baboon tissues and identify significant associations with complex traits. The results of this study indicate that some DNA methylation patterns associated with OA are evolutionarily conserved, while others are not. This warrants further investigation in a larger and more phylogenetically diverse sample set.

Keyphrases

dna methylation
genome wide
gene expression
copy number
knee osteoarthritis
rheumatoid arthritis
bone mineral density
high resolution
high throughput
extracellular matrix
bone loss
single cell