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Childhood adversities characterize the heterogeneity in the brain pattern of individuals during neurodevelopment.

Rajan KashyapBharath HollaSagarika BhattacharjeeEesha SharmaUrvakhsh Meherwan MehtaNilakshi VaidyaRose Dawn BharathPratima MurthyDebashish BasuSubodh Bhagyalakshmi NanjayyaRajkumar Lenin SinghRoshan LourembamAmit ChakrabartiKamakshi KartikKartik KalyanramKalyanaraman KumaranGhattu KrishnaveniMurali KrishnaRebecca KuriyanSunita Simon KurpadSylvane DesrivieresMeera PurushottamGareth BarkerDimitri Papadopoulos OrfanosMatthew HickmanJon HeronMireille ToledanoGunter SchumannVivek Benegalnull null
Published in: Psychological medicine (2024)
Adversities (particularly abuse) maximally influence the DMN during neurodevelopment and lead to the failure in the development of a coherent DMN system. While DMN's integrity is preserved in typical development, the age-dependent variability in atypically developing individuals is contrasting. The flexibility of DMN might be a compensatory mechanism to protect an individual in an abusive environment. However, such adaptability might deprive the neural system of the faculties of normal functioning and may incur long-term effects on the psyche.
Keyphrases
  • single cell
  • young adults
  • early life