Mother-to-child transmission of hepatitis B: Examining viral cut-offs, maternal HBsAg serology and infant testing.
Cynthuja ThilakanathanGabrielle WarkMichael MaleyScott DavisonJoseph LawlerAimei LeeNicholas ShackelVi NguyenKathy JacksonAnne GlassStephen A LocarniniMiriam T LevyPublished in: Liver international : official journal of the International Association for the Study of the Liver (2018)
Antiviral therapy initiated at 32 weeks when maternal viral load is ≥6 log10 IU/mL almost completely abrogates transmission. Quantitative HBsAg does not reliably predict high viral load. When maternal viral load is <6 log10 IU/mL, high vaccine efficacy and zero transmission suggests testing infants is of little value.