Hepatitis E virus ORF 1 induces proliferative and functional T-cell responses in patients with ongoing and resolved hepatitis E.
Jana Al-AyoubiPatrick BehrendtBirgit BremerPothakamuri Venkata SuneethaAnett GisaFranziska RinkerMichael P MannsMarkus CornbergHeiner WedemeyerAnke R M KraftPublished in: Liver international : official journal of the International Association for the Study of the Liver (2017)
HEV-specific T-cell responses are detectable against the entire HEV genome including the non-structural proteins. HEV-specific T-cell responses are associated with control of HEV infection. These findings have implications for the design of HEV vaccines.