Leflunomide-induced liver injury: Differences in characteristics and outcomes in Indian and US registries.

Harshad Devarbhavi Marwan S GhabrilHuiman BarnhartMallikarjun PatilSujata RajJiezhun GuNaga ChalasaniHerbert L Bonkovsky

Published in: Liver international : official journal of the International Association for the Study of the Liver (2022)

Leflunomide-induced liver injury is predominantly hepatocellular. Leflunomide hepatotoxicity is more likely accompanied by SCAR, a short latency and a higher mortality in the Indian cohort, with a predominance of females, compared to US DILIN patients. The differences in skin involvement, immunoallergic features and outcomes among subjects from India vs. the USA suggest that genetic or environmental factors are important in the pathogenesis of liver injury.

Keyphrases

liver injury
drug induced
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
wound healing
risk factors
gene expression
adipose tissue
skeletal muscle
soft tissue
copy number
patient reported
weight loss