Mass Balance Study of the Engineered Cationic Antimicrobial Peptide, WLBU2, Following a Single Intravenous Dose of 14C-WLBU2 in Mice.
Jan H BeumerJianxia GuoEvan C RayJonas ScemamaRobert A PariseBerthony DeslouchesJonathan D SteckbeckRonald C MontelaroJulie L EisemanPublished in: Current reviews in clinical and experimental pharmacology (2022)
WLBU2 distributes widely to mouse tissues and is rapidly cleared with a terminal radioactivity half-life of 22 h, a clearance of 27.4 mL/h/kg, and a distribution volume of 0.94 L/kg. At 2-100 μg-eq/g, the concentrations of 14C-WLBU2 appear high enough in the tissues to account for the inhibition of microbial growth.