Three new diphenyl ethers from the lichen Parmotrema praesorediosum (Nyl.) Hale (Parmeliaceae).
Nguyen Kim Tuyen PhamVan Muoi BuiKim Phi Phung NguyenNguyen Kim Tuyen PhamTan Phat NguyenPublished in: Natural product research (2020)
Three new diphenyl ethers, named praesorethers E, F and G (1, 2 and 3), were isolated from the lichen Parmotrema praesorediosum. Their chemical structures were elucidated on the basis of extensively spectroscopic analysis including HR-ESI-MS and NMR as well as comparison with previously published data. These compounds were evaluated for the cytotoxicity against three human cancer cell lines (HeLa, NCI-H460 and MCF-7) using SRB assay. As results, 1 and 2 exhibited weak cytotoxic activity against three tested cancer cell lines with the inhibitive percentage of 64-79.9% at the concentration of 100 μg/mL while 3 was inactive.
Keyphrases
- papillary thyroid
- ms ms
- squamous cell
- high resolution
- endothelial cells
- magnetic resonance
- mass spectrometry
- multiple sclerosis
- multidrug resistant
- high throughput
- molecular docking
- lymph node metastasis
- squamous cell carcinoma
- machine learning
- breast cancer cells
- systematic review
- cell proliferation
- signaling pathway
- young adults
- molecular dynamics simulations
- data analysis