Standardized Urine-Based Tuberculosis (TB) Screening With TB-Lipoarabinomannan and Xpert MTB/RIF Ultra in Ugandan Adults With Advanced Human Immunodeficiency Virus Disease and Suspected Meningitis.

Fiona V Cresswell Jayne P EllisEnock KagimuAnanta S BangdiwalaMichael OkirwothGerald MugumyaMorris RutakingirwaJohn KasibanteCarson M QuinnKenneth SsebambuliddeJoshua RheinEdwin NuwagiraLillian TugumeEmily MartynCaleb P SkipperConrad MuzooraDaniel GrintDavid B MeyaNathan C BahrAlison M ElliottDavid R Boulware

Published in: Open forum infectious diseases (2020)

In hospitalized Ugandans with advanced HIV disease and suspected meningitis, systematic screening with urine TB-LAM and Ultra found a high prevalence of urine TB test positivity (26%). In those with TB meningitis, urine tests were positive in over one third. There was little concordance between Ultra and TB-LAM, which warrants further investigation.

Keyphrases

mycobacterium tuberculosis
human immunodeficiency virus
pulmonary tuberculosis
antiretroviral therapy
hepatitis c virus
hiv infected
high resolution
hiv aids
hiv positive
cerebrospinal fluid
pulmonary embolism
emergency department
south africa
hiv testing
electronic health record