GSK-3 Inhibition Is Cytotoxic in Glioma Stem Cells through Centrosome Destabilization and Enhances the Effect of Radiotherapy in Orthotopic Models.

Anke Brüning-Richardson Gary C ShawDaniel TamsTim BrendHitesh SanganeeSimon T BarryGregory HammRichard J A GoodwinJohn G SwalesHenry KingLynette SteeleRuth MortonAnastasia WidyadariThomas A WardFilomena EstevesMarjorie BoissinotAlastair DroopSean E LawlerSusan C Short

Published in: Cancers (2021)

These data suggest that GSK-3 inhibition promotes cell death in glioma through disrupting centrosome function and promoting mitotic failure and that AZD2858 is an effective adjuvant to radiation at clinical doses.

Keyphrases

stem cells
cell death
early stage
signaling pathway
pi k akt
radiation induced
radiation therapy
electronic health record
cell cycle
squamous cell carcinoma
cell proliferation