A microenvironment-responsive FePt probes for imaging-guided Fenton-enhanced radiotherapy of hepatocellular carcinoma.
Xingyang ZhaoXiang SunWenchao HuangRonghe ChenKang ChenLiming NieChihua FangPublished in: Journal of nanobiotechnology (2022)
Hepatocellular carcinoma (HCC) continues to be one of the most fatal malignancies with increasing morbidity, and potent therapeutics are urgently required given its insensitivity to traditional treatments. Here, we have developed a microenvironment-responsive FePt probes for the highly efficient Fenton-enhanced radiotherapy (FERT) of HCC. The selective release of Fe 2+ in the acidic tumor microenvironment, but not in normal tissue, together with enhanced levels of hydrogen peroxide produced through the Pt radiosensitization effect, facilitates the generation of an enormous amount of hydroxyl radicals through the Fenton reaction, thereby extending the radiotherapeutic cascade and realizing a powerful therapeutic efficacy for HCC. Moreover, the "burst" release of Fe 2+ contributes to the T2-to-T1 magnetic resonance imaging (MRI) switching effect, which informs the release of Fe 2+ , making imaging-guided cancer therapy feasible. This work not only breaks the bottleneck of traditional radiotherapy for HCC while minimally affecting normal tissues, but also provides a new strategy for FERT imaging guidance.
Keyphrases
- hydrogen peroxide
- cancer therapy
- magnetic resonance imaging
- highly efficient
- high resolution
- early stage
- nitric oxide
- small molecule
- fluorescence imaging
- locally advanced
- stem cells
- radiation therapy
- wastewater treatment
- radiation induced
- drug delivery
- contrast enhanced
- computed tomography
- single molecule
- living cells
- photodynamic therapy
- ionic liquid
- visible light
- rectal cancer