DKK1 is a strong candidate for mesiodens and taurodontism.

Piranit Nik KantaputraPeeranat JatooratthawichotNaomi KottegeRobert P AnthonappaMassupa KaewgahyaSissades TongsimaChumpol NgamphiwJames R Ketudat CairnsDanilo Predes Xi He

Published in: Clinical genetics (2023)

A mutation in DKK1 gene leads to inhibitory DKK1 function, over-activation of WNT/β-catenin signaling, disruptive development of dental epithelium, and subsequent mesiodens formation.

Keyphrases

stem cells
cell proliferation
copy number
genome wide
oral health
gene expression
dna methylation