Pericyte Microvesicles as Plasma Biomarkers Reflecting Brain Microvascular Signaling in Patients With Acute Ischemic Stroke.

Abderahim GacebLinnea RoupéAndreas Enström Wejdan Almasoudi Robert Carlsson Arne G Lindgren Gesine Paul

Published in: Stroke (2024)

We demonstrate that the plasma of patients with acute ischemic stroke reflects (1) an early and time-dependent increase of pericyte-derived microvesicles and (2) changes in the protein cargo of microvesicles over time indicating cell signaling specifically related to inflammation and vascular remodeling.

Keyphrases

acute ischemic stroke
blood brain barrier
oxidative stress
single cell
cell therapy
resting state
cerebral ischemia
stem cells
multiple sclerosis
bone marrow
small molecule
brain injury