A distinct pattern of growth and RAC1 signaling in melanoma brain metastasis cells.
Ioana Stejerean-TodoranPhyllis A GimottyAndrea WattersPatricia BraffordClemens KreplerTetiana GodokHaiyin LiZuriñe Bonilla Del RioAnke ZiesenissDörthe M KatschinskiSinem M SertelSilvio O RizzoliBradley GarmanKatherine L NathansonXiaowei XuQing ChenJack H OswaldMichal LotemGordon B MillsMichael A DaviesMichael P SchönIvan BogeskiMeenhard HerlynAdina VulturPublished in: Neuro-oncology (2022)
Our findings indicate that despite their genetic variability, MBM engage specific molecular processes such as RAC1 signaling to adapt to the brain microenvironment and this can be used for the molecular characterization and treatment of brain metastases.