Hydronidone ameliorates liver fibrosis by inhibiting activation of hepatic stellate cells via Smad7-mediated degradation of TGFβRI.

Xianjun XuYuecheng GuoXin LuoZhenyang ShenZhongshang SunBo ShenCui ZhouJunjun WangJingyi LuQingqing ZhangYanping YeYing LuoYing QuXiaobo CaiHui DongLun-Gen Lu

Published in: Liver international : official journal of the International Association for the Study of the Liver (2023)

Hydronidone ameliorates liver fibrosis by inhibiting HSCs activation via Smad7-mediated TGFβRI degradation. Hydronidone is a potential drug candidate for the treatment of liver fibrosis.

Keyphrases

liver fibrosis
transforming growth factor
epithelial mesenchymal transition
signaling pathway
induced apoptosis
mouse model
cell cycle arrest
pi k akt
endoplasmic reticulum stress
cell death
risk assessment
oxidative stress
cell proliferation
drug induced
electronic health record