Role of Sortilin and Matrix Vesicles in Nε-Carboxymethyl-Lysine-Induced Diabetic Atherosclerotic Calcification.

Lele JingLihua LiXiaomei RenZhen SunZhengyang BaoGuoyue YuanHonghua CaiLin WangChen ShaoZhongqun Wang

Published in: Diabetes, metabolic syndrome and obesity : targets and therapy (2020)

We proved that CML not only affects the release of MVs from SMCs but also affects the recruitment of Sortilin to MVs, thereby promoting diabetic AC. This discovery may provide a new strategy for targeted prevention of vascular calcification in diabetes.

Keyphrases

type diabetes
wound healing
chronic kidney disease
small molecule
cardiovascular disease
high glucose
glycemic control
diabetic rats
high throughput
cancer therapy
drug induced
drug delivery
chronic myeloid leukemia
single cell