Cortical thickness is not associated with current depression in a clinical treatment study.

Greg PerlmanElizabeth BartlettChristine DeLorenzoMyrna WeissmanPatrick McGrathTodd OgdenTony JinPhillip AdamsMadhukar H TrivediBenji KurianMaria OquendoMelvin McInnisSarah WeyandtMaurizio FavaCrystal CooperAshley MalchowRamin Parsey

Published in: Human brain mapping (2017)

Three analytic approaches (i.e., DK atlas, DS atlas, and SBM) converge on the notion that cortical thickness is a relatively weak discriminator of current depression status. Differential age and gender effects do not appear to represent key moderators. Robust associations with demographic factors will likely hinder translation of cortical thickness into a clinically useful biomarker. Hum Brain Mapp, 2017. © 2017 Wiley Periodicals, Inc. Hum Brain Mapp 38:4370-4385, 2017. © 2017 Wiley Periodicals, Inc.

Keyphrases

optical coherence tomography
resting state
depressive symptoms
white matter
functional connectivity
sleep quality
cerebral ischemia
mental health
replacement therapy