The Synergistic Effect of an ATP-Competitive Inhibitor of mTOR and Metformin on Pancreatic Tumor Growth.
Ghada A SolimanSurendra K ShuklaAsserewou EtekpoVenugopal GundaSharalyn M SteensonNagsen GautamYazen AlnoutiPankaj K SinghPublished in: Current developments in nutrition (2020)
The combination of mTOR dual inhibition by Torin 2 and metformin is associated with an altered metabolomic profile and a significant reduction in pancreatic tumor burden compared with single-agent therapy, and it is better tolerated.
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