Transcription factor 12-mediated self-feedback regulatory mechanism is required in DUX4 fusion leukaemia.

Zhihui LiMinghao JiangJunfei WangZhiyi ZhuoShiyan ZhangYangxia TanWeiguo HuHao Zhang Guoyu Meng

Published in: Clinical and translational medicine (2023)

Transcription factor 12 (TCF12) is a new novel cofactor in IGH::DUX4 transcriptional complexes/machinery. TCF12 mediates a positive self-feedback regulatory mechanism in IGH::DUX4-driven oncogenic transaction. IGH::DUX4-TCF12 structure/cooperation might represent a potent target/direction in future drug design against B-cell acute lymphoblastic leukaemia.

Keyphrases

transcription factor
dna binding
liver failure
genome wide identification
drug induced
respiratory failure
emergency department
oxidative stress
anti inflammatory
extracorporeal membrane oxygenation
acute respiratory distress syndrome
electronic health record