Cytotoxic effects of submicron- and nano-scale titanium debris released from dental implants: an integrative review.
Redouane MessousBruno HenriquesHassan BousbaaFilipe S SilvaWim TeughelsJúlio César Matias de SouzaPublished in: Clinical oral investigations (2021)
Titanium ions and debris have been detected in peri-implant tissues with different size, concentration, and forms. The presence of metallic debris at peri-implant tissues also stimulates the migration of immune cells and inflammatory reactions. Cp Ti and TiO2 micro- and nano-scale particles can reach the bloodstream, accumulating in lungs, liver, spleen, and bone marrow.