Digoxin targets low density lipoprotein receptor-related protein 4 and protects against osteoarthritis.
Kai-di WangXiang DingNan JiangChao ZengJing WuXian-Yi CaiAubryanna HettinghouseAsya KhleborodovaZi-Ning LeiZhe-Sheng ChenGuang-Hua LeiChuan-Ju LiuPublished in: Annals of the rheumatic diseases (2021)
These findings not only provide new insights into the understanding of digoxin's chondroprotective action and underlying mechanisms, but also present new evidence for repurposing digoxin for OA.