A convenient catalytic method for preparation of new tetrahydropyrido[2,3- d ]pyrimidines via a cooperative vinylogous anomeric based oxidation.

In this study, a novel functionalized metal-organic frameworks MIL-125(Ti)-N(CH 2 PO 3 H 2 ) 2 was designed and synthesized via post-modification methodology. Then, MIL-125(Ti)-N(CH 2 PO 3 H 2 ) 2 as a mesoporous catalyst was applied for the synthesis of a wide range of novel tetrahydropyrido[2,3- d ]pyrimidines as bioactive candidate compounds by one-pot condensation reaction of 3-(1-methyl-1 H -pyrrol-2-yl)-3-oxopropanenitrile, 6-amino-1,3-dimethylpyrimidine-2,4(1 H ,3 H )-dione and aromatic aldehydes at 100 °C under solvent-free condition. Interestingly, the preparation of tetrahydropyrido[2,3- d ]pyrimidine was achieved via vinylogous anomeric based oxidation mechanism with a high yield and short reaction time.