Chimeric virus-like particles presenting tumour-associated MUC1 epitope result in high titers of specific IgG antibodies in the presence of squalene oil-in-water adjuvant: towards safe cancer immunotherapy.
Mirosława PanasiukKarolina ZimmerAnna CzarnotaMagdalena NarajczykGrażyna Peszyńska-SularzMilena ChraniukLilit HovhannisyanSabina ŻołędowskaDawid NidzworskiAnna J ŻaczekBeata GromadzkaPublished in: Journal of nanobiotechnology (2022)
The obtained results show that immunization with recombinant chimeric NoV VP1- MUC1 VLPs result in high titers of MUC1 specific IgG antibodies and show great therapeutic potential as a platform to present tumour-associated antigens.