A Case of Atopic Dermatitis exacerbation in a patient with Eosinophilic Granulomatosis with Polyangiitis treated with Mepolizumab and successfully managed with Dupilumab combination.

We report a 60-year-old male with eosinophilic granulomatosis with polyangiitis (EGPA) complicated with atopic dermatitis (AD). The patient was initially treated with prednisolone, cyclosporine A and mepolizumab (MEPO). Due to worsening skin symptoms after prednisolone tapering, dupilumab (DUP) was added as an adjunctive therapy for AD confirmed by skin biopsy. The combination therapy of MEPO and DUP resulted in rapid improvement of skin symptoms, suggesting it may be an effective therapeutic option for patients with EGPA and AD. This case report emphasizes the importance of a multidisciplinary approach in treating complex diseases such as EGPA and AD.