Protective and curative effects of unconjugated bilirubin on gene expression of LOX-1 and iNOS in the heart of rats receiving high-fat diet and low dose streptozotocin: a histomorphometric approach.
Mohammad Hassan MalekiOmid VakiliRamin TavakoliElham NadimiZahra NooriMotahareh TaghizadehAmir Reza DehghanianLobat TayebiSayed Mohammad ShafieePublished in: Journal of inflammation (London, England) (2024)
These findings demonstrate that mild hyperbilirubinemia can protect against the progression of atherosclerosis and heart failure by improving lipid profile, modulating adhesion molecules, LOX-1, and iNOS gene expression levels.
Keyphrases
- high fat diet
- gene expression
- heart failure
- low dose
- insulin resistance
- adipose tissue
- dna methylation
- nitric oxide synthase
- atrial fibrillation
- cardiovascular disease
- signaling pathway
- high dose
- left ventricular
- low density lipoprotein
- metabolic syndrome
- escherichia coli
- oxidative stress
- cystic fibrosis
- skeletal muscle
- diabetic rats
- cell migration