[Analysis of the association of polymorphic variants of SYP1A2, GSTT1,GSTM1, GSTP1, XRCC1, XRCC3, AR and VDR genes with predisposition to the development of prostate cancer].
M D KanaevaM V DobrogorskayaG M ZharinovD N MaistrenkoI M SpivakL E VorobtsovaPublished in: Voprosy onkologii (2019)
One of the risk factors for the development of malignant tumors, including prostate cancer, is an individual genetic predisposition due to the various unfavorable polymorphic variants of normal genes. The aim of the study was to com- pare the frequency of different genotypes of polymorphic vari- ants of genes CYPJA2, GSTT, GSTM, GSTP1 (xenobiotics detoxification), XRCC1, XRCC3,(DNA repair) and VDR, AR (transcription factors) in patients with prostate cancer and in control group to determine their association with genetic pre- disposition to this disease. According to the results obtained the rs1544410 AA genotype (VDR gene) and the presence of less than 20 CAG repeats in the 1st exon (AR gene) are the risk factors for the development of prostate cancer. The het- erozygous genotype 722 CT (XRCC3 gene) demonstrated the protective effect.
Keyphrases
- dna repair
- prostate cancer
- genome wide
- copy number
- genome wide identification
- dna damage
- radical prostatectomy
- transcription factor
- dna methylation
- dna damage response
- genome wide analysis
- magnetic resonance imaging
- computed tomography
- bioinformatics analysis
- magnetic resonance
- oxidative stress
- dual energy
- dna binding