[Study of the functional significance of polymorphic loci of the LOXL1 gene associated with glaucoma according to genome-wide studies (in silico analysis)].

N V Eliseeva I V Ponomarenko Mikhail I Churnosov

Published in: Vestnik oftalmologii (2021)

Polymorphic loci of the LOXL1 gene (rs2165241, rs4886776, and rs893818) are of great functional importance (epigenetic, eQTL, and sQTL), which may be the biomedical basis of their associations with glaucoma.

Keyphrases

genome wide
dna methylation
copy number
gene expression
optic nerve
molecular dynamics simulations
genome wide analysis