Indoleamine 2,3-Dioxygenase-Dependent Neurotoxic Kynurenine Metabolism Contributes to Poststroke Depression Induced in Mice by Ischemic Stroke along with Spatial Restraint Stress.
Young Soo KooHyunha KimJung Hwa ParkMin Jae KimYong Il ShinByung Tae ChoiSeo-Yeon LeeHwa Kyoung ShinPublished in: Oxidative medicine and cellular longevity (2018)
Our results suggest that the IDO1-dependent neurotoxic kynurenine metabolism induced by microglia functions in PSD pathogenesis. The beneficial effect of aripiprazole on depressive-like behavior and cognitive impairment may be mediated by inhibition of IDO1, HAAO, QUIN, and ROS.