Cilostazol inhibits hyperglucose-induced vascular smooth muscle cell dysfunction by modulating the RAGE/ERK/NF-κB signaling pathways.
Sheng-Chiang SuYi-Jen HungChia-Luen HuangYi-Shing ShiehChu-Yen ChienChi-Fu ChiangJhih-Syuan LiuChieh-Hua LuChang-Hsun HsiehChien-Ming LinChien-Hsing LeePublished in: Journal of biomedical science (2019)
Both in vitro and in vivo experimental diabetes models showed novel signal transduction of cilostazol-mediated protection against HG-related VSMC dysfunction, and highlighted the involvement of RAGE signaling and downstream pathways.
Keyphrases
- signaling pathway
- smooth muscle
- pi k akt
- oxidative stress
- induced apoptosis
- epithelial mesenchymal transition
- type diabetes
- diabetic rats
- cardiovascular disease
- single cell
- high glucose
- drug induced
- cell proliferation
- glycemic control
- fluorescent probe
- immune response
- mesenchymal stem cells
- bone marrow
- toll like receptor