Regulation of oxytocin receptor gene expression in obsessive-compulsive disorder: a possible role for the microbiota-host epigenetic axis.

Claudio D'AddarioMariangela PucciFabio BelliaAntonio GirellaAnnalaura SabatucciFederico FantiMatteo VismaraBeatrice BenattiLuca FerraraFederica FascianaLaura CelebreCaterina ViganòLuca ElliManuel SergiMauro MaccarroneValeria BuzzelliViviana TrezzaBernardo M Dell'Osso

Published in: Clinical epigenetics (2022)

This is the first demonstration of an interplay between microbiota modulation and epigenetic regulation of gene expression in OCD, opening new avenues for the understanding of disease trajectories and for the development of new therapeutic strategies.

Keyphrases

gene expression
obsessive compulsive disorder
dna methylation
deep brain stimulation
depressive symptoms
binding protein