Targeted Hyaluronate-Hollow Gold Nanosphere Conjugate for Anti-Obesity Photothermal Lipolysis.
Jung Ho LeeHyeon Seon JeongDong Hyun LeeSongeun BeackTaeyeon KimGeon-Hui LeeWon Chan ParkChulhong KimKi Su KimSei Kwang HahnPublished in: ACS biomaterials science & engineering (2017)
Obesity is associated with the risk of developing several severe diseases, such as metabolic disorder, diabetes, and heart diseases. Despite wide investigation and trials, a noninvasive obesity therapy is still an important medical unmet need, targeting the abnormal adipose tissue. Here, we developed hyaluronate-hollow gold nanosphere-adipocyte-targeting peptide (HA-HAuNS-ATP) conjugates for the photothermal ablation of adipose tissues. The HA-HAuNS-ATP conjugate could be noninvasively delivered into the skin and effectively target to adipocytes in the subcutaneous. With near-infrared laser illumination, HA-HAuNS-ATP conjugate enabled highly effective photothermal ablation of adipose tissues in C57BL/6 obesity mice. The photoacoustic imaging confirmed the successful transdermal delivery and the photothermal lipolysis of HA-HAuNS-ATP conjugate. Taken together, the transdermal HA-HAuNS-ATP conjugate might have a great potential for noninvasive photothermal lipolysis.
Keyphrases
- cancer therapy
- adipose tissue
- insulin resistance
- high fat diet induced
- drug delivery
- high fat diet
- metabolic syndrome
- type diabetes
- weight loss
- weight gain
- heart failure
- gene expression
- glycemic control
- skeletal muscle
- healthcare
- photodynamic therapy
- cardiovascular disease
- drug release
- high resolution
- bone marrow
- risk assessment
- fluorescence imaging
- physical activity
- highly efficient
- metal organic framework
- early onset