Immune Activity and Response Differences of Oncolytic Viral Therapy in Recurrent Glioblastoma: Gene Expression Analyses of a Phase IB Study.

Katherine E MillerKevin A CassadyJustin C RothJennifer ClementsKathleen M Schieffer Kristen LeraasAnthony R MillerNripesh PrasadJianmei Wu Leavenworth Inmaculada B AbanRichard J WhitleyG Yancey Gillespie Elaine R Mardis James M Markert

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)

Our data support that the oHSV-induced type I IFN production and the subsequent recruitment of an adaptive immune response differed between enrolled patients and showed association with survival duration in patients with recurrent malignant glioma after treatment with an early generation oHSV.

Keyphrases

immune response
gene expression
end stage renal disease
ejection fraction
newly diagnosed
dendritic cells
chronic kidney disease
peritoneal dialysis
sars cov
prognostic factors
electronic health record
machine learning
stem cells
big data
oxidative stress
deep learning