Inhibition of deubiquitination by PR-619 induces apoptosis and autophagy via ubi-protein aggregation-activated ER stress in oesophageal squamous cell carcinoma.

Longhao WangMiaomiao LiBeibei ShaXuanyu HuYaxin SunMingda ZhuYan XuPingping LiYating WangYanyan GuoJiangfeng LiJianxiang ShiPei LiTao HuPing Chen

Published in: Cell proliferation (2020)

Our findings reveal an unrecognized mechanism for the cytotoxic effects of general DUBs inhibitor (PR-619) and imply that targeting DUBs may be a potential anti-ESCC strategy.

Keyphrases

squamous cell carcinoma
cell death
endoplasmic reticulum stress
oxidative stress
genome wide
signaling pathway
cancer therapy
protein protein
lymph node metastasis
human health
amino acid
locally advanced
binding protein
risk assessment
dna methylation
radiation therapy
gene expression
rectal cancer