CD137 Signaling Promotes Endothelial Apoptosis by Inhibiting Nrf2 Pathway, and Upregulating NF-κB Pathway.

Tianxin GengYang YanYue ZhangLiangjie XuGuangyao ZangJin Chuan Yan

Published in: Mediators of inflammation (2020)

Our results showed that CD137 signaling promotes ECs apoptosis through prooxidative and proinflammatory mechanisms, mediated by Nrf2 and NF-κB pathways, respectively.

Keyphrases

oxidative stress
signaling pathway
cell cycle arrest
pi k akt
endoplasmic reticulum stress
lps induced
cell death
nuclear factor
nk cells
inflammatory response
immune response
cell proliferation
toll like receptor