Multitracer model for staging cortical amyloid deposition using PET imaging.
Lyduine E CollijFiona HeemanGemma SalvadóSilvia IngalaDaniele AltomareArno de WildeElles KonijnenbergMarieke van BuchemMaqsood M YaqubPawel MarkiewiczSandeep S V GollaLyduine E CollijAlle Meije WinkPieter Jelle VisserCharlotte E TeunissenAdriaan A LammertsmaPhilip ScheltensWiesje Maria van der FlierRonald BoellaardBart N M van BerckelJosé Luis MolinuevoJuan-Domingo GispertMark E SchmidtFrederik BarkhofIsadora Lopes Alvesnull nullnull nullPublished in: Neurology (2020)
The pooled multitracer staging model successfully classified the level of amyloid burden in >3,000 individuals across cohorts and radiotracers and detects preglobal amyloid burden and distinct risk profiles of cognitive decline within globally amyloid-positive individuals.